Mario Capecchi's Publications:

Capecchi, M. R. and G. N. Gussin (1965). Suppression in vitro:  Identification of a serine-tRNA as a "Nonsense Suppressor." Science149:417-422.

Adams, J. M. and M. R. Capecchi (1966). N-formylmethionine-tRNA as the initiator of protein syntheses. Proc. Natl. Acad. Sci. USA55:147-155.

Capecchi, M. R. (1966). Initiation of E. coli proteins. Proc. Natl. Acad. Sci. USA55:1517-1524.

Capecchi, M. R. (1966). Cell-free protein synthesis programmed with R17 RNA:  Identification of two phage proteins. J. Mol. Biol. 21:173-193.

Bergquist, P. L. and M. R. Capecchi (1966). Fractionation of a suppressor tRNA. J. Mol. Biol.19:202-206.

Gussin, G. N., M. R. Capecchi, J. M. Adams, J. E. Argetsinger, J. Tooze, K. Weber and J. D. Watson (1966).  Protein synthesis directed by RNA phage messengers.  Cold Spring Harbor Symp. Quant. Biol. 31:257-271.

Capecchi, M. R. (1967). Polycistronic messenger RNA and the phenomenon of suppression, BBA Library.  In Regulation of Nucleic Acid and Protein Synthesis (V. V. Konigsberger and L. Bosch, Ed.), Vol. 10, pp. 243-258.  Amsterdam:  Elsevier Publishing Co.

Capecchi, M. R. (1967). A rapid assay for polypeptide chain termination. Biophys. Res. Comm. 28:773-778.

Capecchi, M. R. (1967). Polypeptide chain termination in vitro:  Isolation of a release factor. Proc. Natl. Acad. Sci. USA58:1144-1151.

Capecchi, M. R. (1967). Polarity in vitro. J. Mol. Biol. 30:213-217.

Capecchi, M. R. and H. A. Klein (1969). Characterization of three proteins involved in polypeptide chain termination. Cold Spring Harbor Symp. Quant. Biol. 28:469-477.

Capecchi, M. R. and H. A. Klein (1970). Release factors mediating termination of complete proteins. Nature26:1029-1033.

Klein, H. A. and M. R. Capecchi (1971). Polypeptide chain termination, purification of the release factors, R1 and  R2 from Escherichia coli. J. Biol. Chem. 246:1055-1061.

Sharp, J. D., N. E. Capecchi and M. R. Capecchi (1973). Altered enzymes in drug resistant variants of mammalian tissue culture cells. Proc. Natl. Acad. Sci. USA70:4732-4736.

Capecchi, M. R., N. E. Capecchi, S. H. Hughes and G. M. Wahl (1974). Selective degradation of abnormal proteins in mammalian tissue culture cells. Proc. Natl. Acad. Sci. USA71:4732-4736.

Hughes, S. H., G. M. Wahl and M. R. Capecchi (1975). Purification and characterization of mouse hypoxanthine-guanine phosphoribosyl transferase. J. Biol. Chem. 250:120-126.

Wahl, G. M., S. H. Hughes and M. R. Capecchi (1975). Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: Evidence for mutations at different loci n the HGPRT gene. J. Cell Phys. 85:307-320.

Capecchi, M. R., S. H. Hughes and G. M. Wahl (1975). Yeast super suppressors are altered tRNAs capable of translating a nonsense codon in vitro. Cell6:269-277.

Capecchi, M. R. and R. E. Webster (1975). Bacteriophage RNA as template for in vitro protein synthesis.  In RNA Phages (N. D. Zinder, Ed.).  Pp. 279-299.  Cold Spring Harbor, New York:  Cold Spring Harbor Press.

Capecchi, M. R., R. A. V. Haar, N. E. Capecchi and M. M. Sveda (1977). The isolation of a suppressible nonsense mutant in mammalian cells. Cell12:371-381.

Capecchi, M. R., R. A. V. Haar, N. E. Capecchi and M. M. Sveda (1977). Molecular approaches to eucaryotic genetic systems. ICN-UCLA Symposia8:381-398.

Capecchi, M. R., R. A. V. Haar and M. M. Sveda (1978). Characterization of nonsense mutants in mammalian cells in culture.  In Mutations and tRNA Nonsense Suppressors (J. E. Celis and J. D. Smith, Eds.).  New York:  Academic Press.  

Capecchi, M. R. (1980). High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell22:479-488.

Folger, K. R., E. A. Wong, G. Wahl and M. R. Capecchi (1982). Patterns of integration of DNA microinjected into cultured mammalian cells:  Evidence for homologous recombination between injected plasmid DNA molecules. Mol. Cell. Biol. 2:1372-1387.

Hudziak, R. M., F. A. Laski, U. L. R. Bhandary, P. A. Sharp and M. R. Capecchi (1982). Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell31:137-146.           

Luciw, P. A., J. M. Bishop, H. E. Varmus and M. R. Capecchi (1983). Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell33:705-716.

Young, J. F., M. R. Capecchi, F. A. Laski, U. L. R. Bhandary, P. A. Sharp and P. Palese (1983). Measurement of suppressor transfer RNA activity. Science221:873-875.

Folger, K. R., K. R. Thomas and M. R. Capecchi (1984). Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harbor Symp. Quant. Biol.49:123-138.

Laski, F. A., R. Belagaje, R. M. Hudziak, M. R. Capecchi, G. P. Norton, P. Palese, U. L. R. Bhandary and P. A. Sharp (1984). Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. EMBO J. 3:2445-2452.

Folger, K. R., K. R. Thomas and M. R. Capecchi (1985). Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol. Cell. Biol. 5:59-69.

Folger, K. R., K. R. Thomas and M. R. Capecchi (1985). Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol. Cell. Biol. 5:70-74.

Frels, W. I., J. A. Bluestone, R. J. Hodes, M. R. Capecchi and D. S. Singer (1985). Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science228:577-580.

Wong, E. A. and M. R. Capecchi (1985). Effects of cell cycle position on transformation by microinjection. Somat. Cell Mol. Genet. 11:45-51.

Goddard, J. M., J. J. Weiland and M. R. Capecchi (1986). Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the V-abl oncogene. Proc. Natl. Acad. Sci. USA83:2172-2176.

Thomas, K. R., K. R. Folger and M. R. Capecchi (1986). High frequency targeting of genes to specific sites in the mammalian genome. Cell44:419-428.

Wong, E. A. and M. R. Capecchi (1986). Analysis of homologous recombination in cultured mammalian cells in a transient expression and a stable transformation assay. Somat. Cell Mol. Genet. 12:63-72.

Thomas, K. R., and M. R. Capecchi (1986). Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature324:34-38.

Thomas, K. R. and M. R. Capecchi (1986). Targeting of genes to specific sites in the mammalian genome. Cold Spring Harbor Symp. Quant. Biol. 51:1101-1113.

Wong, E. A. and M. R. Capecchi (1987). Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. Mol. Cell. Biol. 7:2294-2295.

Thomas, K. R. and M. R. Capecchi (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.

Mansour, S. L., K. R. Thomas and M. R. Capecchi (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells:  A general strategy for targeting mutations to nonselectable genes. Nature336:348-352.

Capecchi, M. R. (1989). Altering the genome by homologous recombination. Science244:1288-1292.

Capecchi, M. R., K. R. Thomas and S. L. Mansour (1989). Creating mice with specific mutations by gene targeting. In Molecular Genetics of Early Drosophila and Mouse Development (M. R. Capecchi, Ed.). Pp. 45-52.  Cold Spring Harbor, New York:  Cold Spring Harbor Press.

Capecchi, M. R. (1989). The new mouse genetics:  altering the genome by gene targeting. Trends Genet. 5:70-76.

Mansour, S. L., K. R. Thomas, C. Deng and M. R. Capecchi (1990). Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.  Proc. Natl. Acad. Sci. USA87:7688-7692.

Thomas, K. R. and M. R. Capecchi (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature346:847-850.

Capecchi, M. R. (1990). Tapping the cellular telephone. Nature344:105.

Capecchi, M. R. (1990). How efficient can you get? Nature348:109.

Chisaka, O. and M. R. Capecchi (1991). Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature350:473-479.

Thomas, K. R., T. A. Musci, P. E. Neumann and M. R. Capecchi (1991). Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell67:969-976.

Chisaka, O., T. S. Musci and M. R. Capecchi (1992). Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene hox-1.6. Nature355:516-520.

Deng, C. and M. R. Capecchi (1992). Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. Cell. Biol. 12:3365-3371.

Thomas, K. R., C. Deng and M. R. Capecchi (1992). High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.  Mol. Cell. Biol. 12:2919-2923.

Mansour, S. L., J. M. Goddard and M. R. Capecchi (1993). Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development117:13-28.

Deng, C., K. R. Thomas and M. R. Capecchi (1993). Location of crossovers during gene targeting with insertion and replacement vectors. Mol. Cell. Biol. 13:2134-2140.

Capecchi, M. R. (1993). YACs to the rescue. Nature362:205-206.

Carpenter, E. M., J. M. Goddard, O. Chisaka, N. R. Manley and M. R. Capecchi (1993). Loss of Hoxa-1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development118:1063-1075.

          

Condie, B. G. and M. R. Capecchi (1993).  Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis.  Development 119:579-595.

Capecchi, M. R. (1994).  Targeted gene replacement.  Sci. Am. 270:54-61.

Kostic, D. and M. R. Capecchi (1994).  Targeted disruptions of the murine hoxa-4 and hoxa-6 genes result in homeotic transformations of components of the vertebral column.  Mech. Dev. 46:231-247.

Davis, A. P. and M. R. Capecchi (1994).  Axial homeosis and appendicular skeleton defects in mice with targeted disruption of hoxd-11Development120:2187-2198.

Condie, B. G. and M. R. Capecchi (1994).  Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions.  Nature370:304-307.

Spyropoulos, D. D. and M. R. Capecchi (1994).  Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.  Genes Dev. 8:1949-1961.

Rancourt, D. E., T. Tsuzuki and M. R. Capecchi (1995).  Genetic interaction betweeen hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.  Genes Dev. 9:108-122.

Capecchi, M. R. (1995).  A personal view of gene targeting.  In Accomplishments in Cancer Research 1994.  (J. G. Fortner and J. E. Rhoads, Ed.)  Philadelphia:  J. B. Lippincott, pp. 67-78. 

Manley, N.R. and M.R. Capecchi (1995).  The role of hoxa-3 in mouse thymus and thyroid development.  Development121:1989-2003.

Davis, A.P., D.P. Witte, H.M. Hsieh-Li, S.S. Potter and M.R. Capecchi (1995).  Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11Nature375:791-796.

Capecchi, M.R. (1995).  The molecular genetic analysis of mouse development.  In Seminars in Developmental Biology.  (M.R. Capecchi, Ed.)  London: Academic Press 6:233-237.                                                                                                                       

Zeiher, B.G., E. Eichwald, J. Zabner, J.J. Smith, A.P. Puga, P.B. McCray, Jr., M.R. Capecchi, M.J. Welsh, and K.R. Thomas (1995).  A mouse model for the D-F508 allele of cystic fibrosis.  J. Clin. Invest. 96:2051-2064.

Davis, A.P. and M.R. Capecchi (1996).  A mutational analysis of the 5' Hox D genes:  Dissection of genetic interactions during limb development in the mouse.  Development  122:1175-1185.

Delort, J.P. and M.R. Capecchi (1996).  TAXI/UAS:  a molecular switch to control expression of genes in vivoHum. Gene Ther. 7:809-820.    

Boulet, A.M. and M.R. Capecchi (1996).  Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.  Dev. Biol. 177:232-249.

Esther, C. R., Jr., T. E. Howard, E. M. Marino, J. M. Goddard, M. R. Capecchi and K. E. Bernstein  (1996).  Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.  Lab. Invest. 74:953-965.

Goddard, J. M., M. Rossel, N. R. Manley and M. R. Capecchi  (1996).  Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.  Development 122:3217-3228.

Barrow, J. R. and M. R. Capecchi (1996).  Targeted disruption of the hoxb-2 locus in mice interferes with expression of hoxb-1 and hoxb-4Development122:3817-3828.

Esther, C. R., Jr., T. E. Howard, Y. Zhou, M. R. Capecchi, M. B. Marrero and K. E. Bernstein (1996).  Lessons from angiotensin-converting enzyme-deficient mice.  Curr. Opin. Nephrol. Hypertens. 5:463-467.    

Capecchi, M. R. (1996).  Function of homeobox genes in skeletal development.  In Molecular and Developmental Biology of Cartilage, Vol. 785.  (B. de Crombrugghe, W. A. Horton, B. R. Olsen, and F. Ramirez, Eds.)  Ann. N. Y. Acad. Sci. 785:34-37.

Chen, F. and M. R. Capecchi (1997).  Targeted mutations in Hoxa-9 and Hoxb-9 reveal synergistic interactions.  Dev. Biol. 181:186-196.

Humphries, M. M., D. Rancourt, G. J. Farrar, P. Kenna, M. Hazel, R. A. Bush, P. A. Sieving, D. M. Sheils, N. McNally, P. Creighton, A. Erven, A. Boros, K. Gulya, M. R. Capecchi and P. Humphries (1997).  Retinopathy induced in mice by targeted disruption of the rhodopsin gene.  Nature Genet.15:216-219.

Thomas, K. R. and M. R. Capecchi (1997).  Recombinant DNA technique and sickle cell anemia research.  Science. 275:1404-1405.

Capecchi, M. R. (1997).  The role of Hox genes in hindbrain development.  In Molecular and Cellular Approaches to Neural Development.  (W.M. Cowan, T.M. Jessell and S.L. Zipursky, Eds.)  New York:  Oxford University Press, pp. 334-355.

Esther, C. R., Jr., E. M. Marino, T. E. Howard, A. Machaud, P. Corvol, M. R. Capecchi and K. E. Bernstein (1997).  The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.  J. Clin. Invest. 99:2375-2385.

Carpenter, E. M., J. M. Goddard, A. P. Davis, T. P. Nguyen and M. R. Capecchi (1997).  Targeted disruption of Hoxd10 affects mouse hindlimb development.  Development 124:4505-4514.

Capecchi, M. R. (1997).  Hox genes and mammalian development.  In Cold Spring Harbor Symposia on Quantitative Biology:  Pattern Formation during Development.  Vol. LXII.  Cold Spring Harbor, NY:  Cold Spring Harbor Laboratory Press, pp. 273-281.

Condie, B. C., G. Bain, D. I. Gottlieb and M. R. Capecchi (1997).  Cleft palate in mice with a targeted mutation in the g-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc. Natl. Acad. Sci. USA94:11451-11455. 

Manley, N. R. and M. R. Capecchi (1997).  Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures.  Dev. Biol.192:274-288.

Wilder, P. J., D. Kelly, K. Brigman, C. L. Peterson, T. Nowling, Q.-S. Gao, R. D. McComb, M. R. Capecchi and A. Rizzino (1997).  Inactivation of the FGF-4 gene in embryonic stem cells alters the growth and/or the survival of their early differentiated progeny.  Dev. Biol. 192:614-629.

Capecchi,  M. R. (1997).  The Making of a Scientist.  In Kyoto Prizes and Inamori Grants 1996.  Kyoto:  The Inamori  Foundation.

Hostikka, S. L. and M. R. Capecchi (1998).  The mouse Hoxc11 gene:  genomic structure and expression pattern.  Mech. Dev. 70:133-145.

Godwin, A. R. and M. R. Capecchi (1998).  Hoxc13 mutant mice lack external hair.  Genes Dev. 12:11-20.

Manley, N. R. and M. R. Capecchi (1998).  Hox group 3 paralogs regulate the development and migration of the thymus, thyroid and parathyroid glands.  Dev. Biol. 195:1-15.

Capecchi, M. R. (1998).  Gene targeting: an historical perspective.  In Novel Systems for the Study of Human Diseases--From Basic Research to Applications.  Pp. 49-54. OECD Proceedings.

Chen, F., J. Greer and M. R. Capecchi (1998).  Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae.  Mech. Dev. 77:49-57.

Godwin, A. R.,  H. S. Stadler, K. Nakamura and M. R. Capecchi. (1998).  Detection of targeted GFP-Hox gene fusions during mouse embryogenesis.  Proc. Natl. Acad. Sci. USA 95:13042-13047.

Chen, F. and M. R. Capecchi.  (1999).  The paralogous mouse Hox genes, Hoxa9, Hoxb9 and Hoxd9, function together to control development of the mammary gland in response to pregnancy.  Proc. Natl. Acad. Sci. USA 96:541-546.

Schmidt, E. E., E. S. Hanson and M. R. Capecchi (1999). Sequence-independent assembly of spermatid mRNAs into mRNP particles.  Mol. Cell. Biol. 19:3904-3915.

 

Bunting, M., K. E. Bernstein, J. M. Greer, M. R. Capecchi and K. R. Thomas (1999).  Targeting genes for self-excision in the germline.  Genes Dev.13:1524-1528.

Barrow, J. R. and M. R. Capecchi (1999).  Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants.  Development 126:5011-5026.

Rossel, M. and M. R. Capecchi (1999).  Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development.  Development126:5027-5040.

Godwin, A. R. and M. R. Capecchi (1999).  Hair defects in Hoxc13 mutant mice.  J. Invest. Dermatol. Symp. Proc. 4:244-247.

Hashimoto, J., G. Murakami, M. H. Tsugane, O. Chisaka, M. R. Capecchi and T. Ogino (1999).  Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences.  Kaibogaku Zasshi 74:609-630.

Capecchi, M. R.  (2000).  Human germline gene therapy:  How and why.  In Engineering the Human Germline.  (G. Stock and J. Campbell, Eds.)  New York:  Oxford University Press, pp. 31-42.

Greer, J. M., J. Puetz, K. R. Thomas and M. R. Capecchi (2000).  Maintenance of functional equivalence during paralogous Hox gene evolution.  Nature 403:661-665.

Barrow, J. R., H. S. Stadler and M. R. Capecchi (2000).  Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.  Development 127:933-944.

Moon, A. M., A. M. Boulet and M. R. Capecchi (2000).  Normal limb development in conditional mutants of Fgf4.  Development 127:989-996.

Capecchi, M. R. (2000).  How close are we to implementing gene targeting in animals other than the mouse?  Proc. Natl. Acad. Sci. USA 97:956-957.

Capecchi, M. R. (2000).  Choose your target.  Nature Genet.26:159-161.

Schmidt, E. E., D. S. Taylor, J. R. Prigge, S. Barnett and M. R. Capecchi (2000).  Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.  Proc. Natl. Acad. Sci. USA 97:13702-13707.

Gaufo, G. O., P. Flodby and M. R. Capecchi (2000).  Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.  Development 127:5343-5354.

Moon, A. M. and M. R. Capecchi (2000).  Fgf8 is required for outgrowth and patterning of the limbs.  Nature Genet.26:455-459.

Cole, J., D. Ertoy, H. Lin, R. L. Sutliff, E. Ezan, T. T. Guyene, M. R. Capecchi, P. Corvol, and K. E. Bernstein (2000).  Mice deficient in angiotensin converting enzyme (ACE) have anemia due to a lack of angiotensin II facilitated erythropoiesis. J. Clin. Invest.106:1391-1398.

Manley, N. R., J. R. Barrow, T. Zhang and M. R. Capecchi (2001).  Hoxb2 and Hoxb4 act together to specify ventral body wall formation.  Dev. Biol.237:130-144.

Stadler, H. S., K. M. Higgins and M. R. Capecchi (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13mutant limbs.  Development 128:4177-4188.

Capecchi, M.R. (2001). Gene targeting: Altering the genome in mice.  Ergito.  http://www.ergito.com/main.jsp?bcs=EXP.3.4

Capecchi, M.R. (2001). Generating mice with targeted mutations.  Nature Med. 7:1086-1090.

Cole, J., D. L. Quach, K. Sundaram, P. Corvol, M. R. Capecchi and K. E. Bernstein (2002).  Mice lacking endothelial ACE have a normal blood pressure.  Circ. Res. 90:87-92.

Greer, J. M. and M. R. Capecchi (2002).  Hoxb8 is required for normal grooming behavior in the mouse.  Neuron 33:23-34.

Wellik, D. M., P. J. Hawkes and M. R. Capecchi (2002).  Hox11 paralogous genes are essential for metanephric kidney induction.  Genes Dev.16:1423-1432.

Hobbs, N. K., A. A. Bondareva, S. Barnett, M. R. Capecchi and E. E. Schmidt (2002).  Removing the vertebrate-specific TBP N-terminus disrupts placental b2m-dependent interactions with the maternal immune system.  Cell110:43-54.

Boulet, A. M. and M. R. Capecchi (2002).  Duplication of the Hoxd11gene causes alterations in the axial and appendicular skeleton of the mouse.  Dev. Biol.249:96-107.

Frank, D. U., L. K. Fotheringham, J. A. Brewer, L. J. Muglia, M. Tristani-Firouzi, M. R. Capecchi and A. M. Moon (2002).  An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.  Development129:4591-4603.

Vorbach, C., A. Scriven and M. R. Capecchi (2002).  The housekeeping gene Xanthine Oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev.16:3223-3235.

Barrow, J. R., K. R Thomas, O. Boussadia-Zahui, R. Moore, R. Kemler, M. R. Capecchi, and A. P. McMahon (2003). Ectodermal Wnt3/b-catenin signaling is required for the establishment and the maintenance of the apical ectodermal ridge.  Genes Dev.17:394-409.

Schmidt, E. E., A. A. Bondareva, J. R. Radke and M. R. Capecchi (2003).  Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein.  J. Biol. Chem.278:6168-6174.

Economides, K. D., L. Zeltser and M. R. Capecchi (2003).  Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.  Dev. Biol.256:317-330.

Cole J., N. Khokhlova, R. L. Sutliff, J. W. Adams, K. M. Disher, H. Zhao, M. R. Capecchi, P. Corvol and K. E. Bernstein (2003).  Mice lacking endothelial angiotensin-converting enzyme (ACE):  normal blood pressure with elevated angiotensin II. Hypertension41:313-321.

Economides, K. R. and M. R. Capecchi (2003).  Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.  Development130:2061-2069.

Arenkiel, B. R., G. O. Gaufo and M. R. Capecchi (2003).  Hoxb1 neural crest preferentially form glia of the PNS.  Dev. Dynamics227:379-386.

Wellik, D. M. and M. R. Capecchi (2003).  Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.  Science301:363-367.

Vorbach, C., R. Harrison and M. R. Capecchi (2003).  Xanthine oxidoreductase is central to the evolution and function of the innate immune system.  Trends Immunol.  29:512-517.

Gaufo, G. O., K. R. Thomas and M. R. Capecchi (2003).  Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motor neurons.  Development130:5191-5201.

Wong, K. H. H., H. D. Wintch and M. R. Capecchi (2004).  Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development.  Molec. Endocrin.  18:184-193.

Boulet, A. M. and M. R. Capecchi (2004). Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod.  Development131:299-309.

Westerberg, R., P. Tvrdik, A. B. Unden, J. E. Mansson, L. Norlen, A. Jakobsson, W. H. Holleran, P. M. Elias, A. Asadi, P. Flodby, R. Toftgard, M. R. Capecchi and A. Jacobsson (2004). Role for ELOVL3 and fatty acid chain length in development of hair and skin function.  J. Biol. Chem. 279:5621-5629.

Gaufo, G.O., S. Wu and M. R. Capecchi (2004).  Contribution of Hox genes to the diversity of the hindbrain sensory system.  Development 131:1259-1266.

Fuchs, S., H. D. Xiao, J. W. Adams,  K. Frenzel, G. Keshelava ,  M. R. Capecchi , P.  Corvol and K. E. Bernstein (2004). Role of the N-terminal catalytic domain of ACE investigated by targeted inactivation in mice.  J. Biol. Chem. 279:15946-15953.

Arenkiel,  B. R., P. Tvrdik, G. O. Gaufo and M. R. Capecchi (2004).  Hoxb1 functions in both motoneurons and tissues of the periphery to establish and maintain the proper neuronal circuitry.  Genes Dev.18:1539-1552.

Boulet, A. M., A. M. Moon, B. R. Arenkiel and M. R. Capecchi (2004).  The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.  Dev. Biol.273:361-372.

Xiao,  H. D., S. Fuchs, D. J. Campbell , W. Lewis, S. C. Dudley, Jr., V. S. Kasi, B. D. Hoit, G. T. Keshelava , H. Zhao, M. R. Capecchi and K. E. Bernstein (2004). Mice with cardiac restricted angiotensin converting enzyme (ACE) have atrial enlargement and sudden death.  Am. J. Path. 165:1019-1032.



Keller, C., M. S. Hansen, C. M. Coffin and M. R. Capecchi (2004).  Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function:  implications for alveolar rhabdomyosarcoma cell of origin.  Genes Dev.  18:2608-2613.

Keller, C., B. R. Arenkiel, C. M. Coffin, N. El-Bardeesy, R. A.  DePinho and M. R. Capecchi (2004).  Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.  Genes Dev.  18:2614-2626.

Capecchi, M.R. (2005).  Essay:  Gene targeting in mice:  functional analysis of the mammalian genome for the twenty-first century.  Nat Rev Genet.  2005 Jun;6(6):507-12.



Schindehutte J, H. Fukumitsu, P. Collombat, G. Griesel, C. Brink, P.C. Baier, M.R. Capecchi, and A. Mansouri (2005). In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells.  Stem Cells, 23(1), 10-15.



Keller, C.B. and M.R. Capecchi.  (2005)  New Genetic Tactics to Model Alveolar Rhabdomyosarcoma in the Mouse.  Cancer Res. Sept. 1; 65(17):7530-32.



Kindlmann G.L., D.M. Weinstein, G.M. Jones, C.R. Johnson, M.R. Capecchi, and C. Keller. (2005) Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.  Molecular Imaging. Oct-Dec;4(4):417-24



Fuchs, S., K. Frenzel K., C. Hubert, R. Lyng, L. Muller, A. Michaud, H.D. Xiao, J.W. Adams, M.R. Capecchi, P. Corvol, B.D. Shur, and K.E. Bernstein (2005).  Male fertility is dependent on dipeptidase activity of testis ACE.  Nat Med. Nov;11(11):1140-2.



Wu, S., Y. Wu, and M.R. Capecchi (2006).  Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo.  Development 133, 581-590.



Johnson, J.T., M.S. Hansen, I. Wu, L.J. Healy, C.R. Johnson, G.M. Jones, M.R. Capecchi, and C. Keller (2006).  Virtual histology of transgenic mouse embryos for high-throughput phenotyping.  PLoS. Apr;2(4):e61.



Westerberg, R., J.E. Mansson, V. Golozoubova, I.G. Shabalina, E.C. Backlund, P. Tvrdik, K. Retterstol, M.R. Capecchi, and A. Jacobsson (2006).  ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue.  J Biol Chem.  Feb. 24;281(8):4958-68.



Vorbach, C., M.R. Capecchi, and J.M. Penninger (2006).  Evolution of the mammary gland from the innate immune system?  Bioessays.  Jun;28(6):606-16.



Frenzel, K., T.A. Wallace, I. McDoom, H.D. Xiao, M.R. Capecchi, K.E. Bernstein, and P.P. Sayeski (2006).  A functional Jak2 tyrosine kinase domain is essential for mouse development.  Exp Cell Res. Sept. 10;312(15):2735-44.



Tvrdik, P. and M.R. Capecchi (2006).  Reversal of Hox1 gene subfunctionalization in the mouse.  Dev Cell. Aug;11(2):239-50.



Haldar, M., J.D. Hancock, C.M. Coffin, S.L. Lessnick, and M.R. Capecchi (2007).  A conditional mouse model of synovial sarcoma:  insights into a myogenic origin.  Cancer Cell. Apr.;11(4):375-388.



Shen, X.Z., P. Li, D. Weiss, S. Fuchs, H.D. Xiao, J.A. Adams, I.R. Williams, M.R. Capecchi, W.R. Taylor, and K.E. Bernstein (2007).  Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.  Am J Pathol. Jun;170(6):2122-34.



Wu, S., G. Ying, Q. Wu, and M.R. Capecchi (2007).  Towards simpler and faster genome-wide mutagenesis in mice.  Nat Genet. Jul;39(7):922-30.  Epub 2007 Jun 17.



McIntyre, D.C., S. Rakshit, A.R. Yallowitz, L. Loken, L. Jeannotte, M.R. Capecchi, and D.M. Wellik (2007).  Hox patterning of the vertebrate rib cage.  Development 134, 2981-89.



Barrow, J.R., W.D. Howell, M. Rule, S. Hayashi, K.R. Thomas, M.R. Capecchi, and A.P. McMahon (2007).  Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev. Biol. 312: 312-20.

Bondareva, A.A., M.R. Capecchi, S.V. Iverson, Y. Li, N.I. Lopez, O. Lucas, G.F. Merrill, J.R. Prigge, A.M. Siders, M. Wakamiya, S.L. Wallin, and E.E. Schmid (2007).  Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.  Free Radic Biol Med. Sept. 15;43(6):911-23.

Wu, Y., G. Wang, S.A. Scott, and M.R. Capecchi (2008).  Hoxc10 and Hoxd10 regulate mouse columnar, divisional, and motor pool identity of lumbar motoneurons.  Development 135(1):171-182.



Vasquez, S.X., M.S. Hansen, A.N. Bahadur, M.F. Hockin, G.L. Kindlmann, L. Nevell, I.Q. Wu, D.J. Grunwald, D.M. Weinstein, G.M. Jones, C.R. Johnson, J.L. Vandeberg, M.R. Capecchi, C. Keller (2008).  Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms. Anat Rec 291(5):475-487.

Wu, S., G. Ying, Q. Wu and M.R. Capecchi (2008).  A protocol for constructing gene targeting vectors:  generating knockout mice for the cadherin family and beyond.  Nat Protocols. 3(6):1056-76.



Haldar, M. G. Karan, P. Tvrdik, and M.R. Capecchi (2008).  Two cell lineages, Myf5-independent, participate in mouse skeletal myogenesis.  Dev Cell Mar(3).:14:437-445.



Haldar, M., R.L. Randall and M. R. Capecchi (2008).  Synovial Sarcoma:  From Genetics to Genetic-based Animal Modeling.  Clin OrthopRelat Res.  Sep;466(9):2156-67. Epub. Jun 18.



Sangiorgi, E. and M.R. Capecchi (2008).  Bmi1 is expressed in vivo in intestinal stem cells.  Nat Genet. Jul;40(7):915-20. Epub Jun 8.



Capecchi, M.R. (2008).  The Making of a Scientist II (Nobel Lecture).  ChemBioChem.  Jul 2;9(10):1530-43. Epub Jun 13.



Sangiorgi, E., Z. Shuhua, and M.R. Capecchi (2008).  In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette. Nuc. Acid Res. 10.1093/nar/gkn627:1-8.



Ray, R., and M.R. Capecchi (2008).  An examination of the chiropteran HoxD locus from an evolutionary perspective. Evol. & Dev. 10:6 657-670



Sangiorgi, E., and M.R. Capecchi (2008).  Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. PNAS (Apr:106(17):7101-7106).

Haldar, M., M. Hedberg, M. Hockin and M.R. Capecchi (2009) A CreER based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res. (15:69(8):3657-64).

Haipeng, X., S. Wu, S.T. Papadeau, S. Spusta, A.M. Swistowska, C.C. MacArthur, M.P. Mattson, N. J. Maragakis, M.R. Capecchi, M.S. Rao, S. Zeng and Y. Liu. (2009) A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cell (accepted).

Suvorova, E. C. Weisend, M.C. Rollins, G. Merrill, M.R. Capecchi, and E. Schmidt. Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd1-Deficient Hepatocytes. PLoS ONE (in press).

Ying, G., S. Wu, R. Hou, W. Huang, M.R. Capecchi, Q. Wu (2009).  The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain.  Mol. Cell. Biol. 29(11): 3056-61 Epub Mar 30.

Taniguchi, E., M.J. Cho, B.R. Arenkiel, M.S. Hansen, O.J. Rivera, A.T. McCleish, S.J. Qualman, D.C. Guttridge, M.P. Scott, M.R. Capecchi and C. Keller (2009). Bortezomib reverses a post-translational mechanism of tumorigenesis for patched 1 haploisufficiency in medulloblastoma. Pediatr. Blood Cancer 53(2) 136-44. 

Nishijo, K., T. Hosoyama, C.R.R. Bjornson, B.S. Schaffer, S.I. Prajapati, A.N. Bahadur, M.S. Hansen, M.C. Blandford, A.T. McCleish, B.P. Rubin, J.A.Epstein, T.A. Rando, M.R. Capecchi and C. Keller (2009).  Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB 23(8): 2681-90 Epub Mar 30.

Ootani, A., X. Li, E. Sangiorgi, Q.T. Ho, H. Ueno, S. Toda, H. Sugihara, K. Fujimoto, I.L. Weissman, M.R. Capecchi and C.J. Kuo (2009).  Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat. Med. 5(6): 701-6 Epub Apr 27.

Sangiorgi, E. and M.R. Capecchi (2009).  Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. PNAS Apr:106(17):7101-7106.

Haldar, M., M. Hedberg, M. Hockin and M.R. Capecchi (2009). A CreER based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res. 15:69(8):3657-64.

Xue, H., S. Wu, S.T. Papadeau, S. Spusta, A.M. Swistowska, C.C. MacArthur, M.P. Mattson, N. J. Maragakis, M.R. Capecchi, M.S. Rao, S. Zeng and Y. Liu. (2009) A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cell 27(8): 1836-46

Suvorova, E., O. Lucas, M.C. Weisend, M.F. Rollins, G. Merrill, M.R. Capecchi, and E. Schmidt. (2009) Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd1-Deficient Hepatocytes. PLoS ONE Jul 7:4(7):e6158.

Jones, K. B., V. Piombo, C. Searby, G. Kurringer, B. Yang, F. Grabellus, P. Roughley, J. Morcuende, J. Buckwalter, M. R. Capecchi, A. Vortkamp and V. C. Sheffield (2010).  A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondroytes.  PNAS 107(5):2054-9. Epub 2009 Dec 22.

Tripathi, P., Q. Guo, Y. Wang, M. Coussens, H. Liapis, S. Jain, M. R. Kuehn, M. R. Capecchi and F. Chen (2010).  Midline signaling regulates kidney positioning but not nephrogenesis through Shh.  Dev Bio. Epub Feb10. 

Makki, N. and M. R. Capecchi (2010).  Hoxa1 linage-tracing indictes a direct role for Hoxa1 in development of the inner ear, the heart and the third rhombomere.  Dev Bio. 341:499–509.

Chen S.C., P. Tvrdik, E. Peden, S. Cho, S. Wu, G. Spangrude, M.R. Capecchi (2010).  Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice. Cell 141(5):775-785. 

Rollins, M.F., D. van der Heide, C. Weisend, J. Kundert, K. Constock, E. Sovorova, M.R. Capecchi, G.F. Merrill and E.E. Schimdt (2010).  Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration. Cell Sci. 123:2402-2412.

Zadravec, D., Tvrdik, P., Guillou, H., Haslam, R., Kobayashi, T., Napier, J.A., Capecchi, M.R., and Jacobsson, A. (2011).  ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.  J Lip Res, 52(2):245-55.

Guo, T., Mandai, K., Condie, B.G., Wickramasinghe, S.R., Wang, F., Capecchi, M.R., and Ginty, D.D (2011).  An evolving NGF-Hoxd1 signaling pathway controls divergent neural circuit development in vertebrates.  Nature Neurosci 14(1):31-6. PMID21151121 

Rubin, B.R., Koichi Nishijo, Hung-I Harry Chen, Xiaolan Yi, David P. Schuetze, Ranadip Pal, Suresh I. Prajapati, Jinu Abraham, Benjamin R. Arenkiel, Qing-Rong Chen, Sean Davis, Amanda T. McCleish, Mario R. Capecchi, Joel E. Michalek, Lee Ann Zarzabal, Javed Khan, Zhongxin Yu, David M. Parham, Frederic G. Barr, Paul S. Meltzer, Yidong Chen , C. Keller (2011).  Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma. Cancer Cell, 19(2):177-91.

Angus-Hill, M.L., Elbert, K. M. Hidalgo, J. and M. R. Capecchi (2011).  T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis.  PNAS 108(12):4914-9. 



Bertrand, N., Roux, M., Ryckebüsch, L., Niederreither, K., Dollé, P., Moon, A., Capecchi, M.R., and S. Zaffran (2011).  Hox genes define distinct progenitor sub-domains within the second heart field  Dev. Biol. 363(2):266-74.



Makki, N. and M.R. Capecchi (2011).  Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev. Bio.  357 295-04.  



Prigge, J. R., Eriksson, S., Iverson, S. V., Meade, T. A. Capecchi, M. R., Arner, E. S. and E. Schmidt (2011). Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.   FRBM (Epub 12/21/11)



Yan, K.S., Chia, L.A., Li, X., Ootani, A., Su, J., Lee, J.Y. Su, N., Luo, Y., Heilshorn, S.C., Amieva, M.R., Sangiorgi, E., Capecchi, M.R. and C. J. Kuo (2011). The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. PNAS (Epub 12/21/2011).



Makki, N. and M.R. Capecchi (2012).  Cardiovascular defects in a mouse model of HOXA1 syndrome. Hum. Mol. Genet. 21(91): 26-31. 



Su, L., Sampaio, A.V., Jones, K.B., Pacheco, M., Goytain, A., Lin, S., Paulin, N., Yi, L., Rossi, F.Y., Kast, J., Capecchi, M.R., Underhill, T.M., and T. O. Nielsen (2012).  Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 21(3) 323-4

Suo, L., H. Lu, G. Ying, M.R. Capecchi and Q. Wu (2012).  Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase.  J Mol. Cell Biol. Sept 11 Epub ahead of print. 



Jones, K.B., Manasi, D., Ravichandran, S., Jin, H., Jurrus, E., Whitaker, R. and M.R. Capecchi. (2012). Toward an understanding of the short bone phenotype associated with multiple osteochrondromas. J Orthop Res. 31(4):651-7, Nov 28. Doi: 10.1002/jor.22280

Rogers, S., Tvrdik, P., Capecchi, M.R., and L. Gahring. (2012). Prenatal Ablation of Nicotinic Receptor alpha7 Cell Lineages Produces Lumbosacral Spina Bifida the Severity of Which is Modified by Choline and Nicotine Exposure. Amer. J. Med. Genet, 158A(5): 1135-44. doi: 10.1002/ajmg.a.35372 (Epub ahead of print Mar 30).

Boulet, A.M. and M.R. Capecchi (2012). Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 1(2): 235-45 doi: 10.1016/j.ydboi.2012.8.017 (Epub ahead of print).

Jones, K.B., L. Su, H. Jin, C. Lenz, R.L. Randall, T.M. Underhill, T.O. Nielson, S. Sharma and M.R. Capecchi. (2012) SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene Jul 16 doi: 10.1038/onc.2012.247 (Epub ahead of print)

Straessler, K.M., K.B. Jones, H. Hu, H. Jin, M. van de Rijn and M.R. Capecchi (2012). Modeling Clear Cell Sarcomagenesis in the Mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell 23(2) 215-27.

Gahring, L.C., Enioutina, E.Y., Myers, E.J., Spangrude, G.J., Efimova, O.V., Kelley, T.W., Tvrdik, P., Capecchi, M.R. and S.W. Rogers (2012). Nicotinic Receptor Alpha7 Expression Identifies a Novel Hematopoietic Progenitor Lineage. Plos ONE 8(3):e57481. PMID 23469197

Iverson, S., S. Eriksson, J. Xu, J.R. Prigge, E.A. Talago, T.A. meade, E.S. Meade, M.R. Capecchi, E.S.J. Arer and E.E. Schmidt (2013). A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. Free Rad. Biol. & Med. (EPub ahead of print) Doi.org/10.1016

 

 

 

 

 

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